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KMID : 0605619990060010089
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Journal of Korean Society of Biological Psychiatry
1999 Volume.6 No. 1 p.89 ~ p.95
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Association of Tardive Dyskinesia with Cognitive Deficit in Schizophrenia
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1전진숙/1Jin Sook Cheon
2오병훈/3장태섭/2Byoung Hoon Oh/3Tae Seob Jan,
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Abstract
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To understand a mechanism of underlying cognitive deficit in schizophrenia, the risk
factors, cognitive function, blood dopamine concentrations and glutamate dehydrogenase
activities of male schizophrenics with tardive dyskinesia(N=30) were compared with
those of schizophrenics without tardive dyskinesia(N=30).
The result were as following ;
1) The age, duration of illness and duration of medication were significantly more in
schizophrenics with tardive dyskinesia than schizophrenics without tardive
dyskinesia(respectively p<0.005, p<0.0001, p<0.0001).
2)The scores of MMSE, TIQ, VIQ and PIQ were significantly lower in schizophrenics
with tradive dyskinesia than schizophrenics without tardive dyskinesia(respectively
p<0.0001).
3) plasma dopamine concentrations were tended to be higher, and serum glutamate
dehydrogenase activities were tended to be lower in schizophrenics with tardive
dyskinesia than schizophrenics without tardive dyskinesia.
4) The cognitive deficit seemed to be negatively correlated with duration of illness and
duration of illness and duration of medication(respectively γ=-0.496, γ=-0.615).
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